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Thanks.   I cut and pasted the EFI section in at 64512 and filled the space following it with FFFF and I now have bootscreens!

Here's my ROM if anyone else has the Powercolor R9 280X 3GB card.

I used this yesterday to fit a Powercolor R9280x into my Mac Pro 5.1 previously recognised as 7xxxx , now comes up as "AMD Radeon R9 280X 3 GB" in Mojave 10.14.6.
However the problem I have this with this card remains, some audio plugins cause a spinning wheel, this is 100% reproducible and I've been trying to solve it for some time. I tried a 7850 and it had the same problem, hence why I thought the R9 280x would solve it. A friend of mine has a 7950 and his same setup doesn't have this problem so I'm confused if its the card itself or the driver OSX is using, has anyone got any suggestions?
Can I change the driver in OSX, maybe I should flash it to a 7950, I think that's possible.
Lastly if I look in the system report it shows 2 entries for the card in PCI , note the second one says no driver installed, maybe that is it?
EDIT I found out this is to do with HDMI display port audio
AMD Radeon R9 280X:

Name:   ATY,Hamachi -Type:   Display Controller-  Driver Installed:   Yes -  MSI:Yes-  Bus:   PCI  Slot:   Slot-1  Vendor ID:   0x1002  Device ID:   0x6798 Subsystem Vendor ID:   0x148c  Subsystem ID:   0x3001  Revision ID:   0x0000  Link Width:   x16  Link Speed:   5.0 GT/s
Then AMD Radeon R9 280X:
 Name:   ATY,HamachiParent  Type:   ATY,HamachiParent  Driver Installed:   No  MSI:   No  Bus:   PCI  Slot:   Slot-1  Vendor ID:   0x1002  Device ID:0xaaa0  Subsystem Vendor ID:   0x148c  Subsystem ID:   0xaaa0  Revision ID:   0x0000  Link Width:   x16  Link Speed:   5.0 GT/s[/right]

A few tips in case it helps others, as it took ages to work out how to do this, despite so many pages I found of google help.
I used a Windows 10 PC for flashing and the Rom posted by Tpluth (thank you) called NEWWC.ROM
Trying to use the latest win flash resulted in it saving 0 bytes then it would blue screen! I tried different versions and removing all video drivers, disabling the card, nothing worked, pretty much the same luck with cmd promt dos window, I repeatedly got the app needed to be run in administrative mode, even though it was.
So I used a thumb drive booted with freedos created via Rufus (google it).
Long names didn't come up properly so I had to rename files to get it to work.
The final atiflash I found working was atiflash 4.17 I tried a lot! Also with the amdbvflash but that told me it doesn't work in dos mode and seeing as windows blue screened then an older version was my only option. It took me a day to sort this through trial and error, I maybe did lots of things wrong but I did get there in the end.

I did managed to save the orig bios using GPUz and  Atiflash 4.17.
If anyone can help me improve my card by modding my original Rom that would be so amazing I'd be forever grateful, I got a bit lost trying to use the script.
Thanks again for this amazing site!

Should question who won't play ball with whom...

Does it really matter? NVIDIA said they will not support CUDA for MacOS any further. That means that there'll be no drivers from now on, unless in the future, they produce drivers that take advantage of metal without CUDA. That is of course in the sphere of silly science fiction.

Should question who won't play ball with whom...

Back on page 15 of this respectfully long thread, in June 2011, I successfully upgraded my at that time not so old Mac Pro 4,1 to a Mac Pro 5,1, using two Xeon X5660 CPUs and 32GB RAM of RAM. At the end of 2016 I upgraded the CPUs to two X5690 CPUs and increased the RAM to 96GB on six 16GB 1333MHz DIMMs to squeeze out the last bit of performance. And in November 2018 I upgraded the Radeon option card for a re-flashed GeForce GTX 680. This machine just keep on going. And going strong at that!

Back in 2011 I had to find out the hard way that NVMe booting wasn't supported; The OCZ Revo X2 PCIe SSD was refundable, but the OWC Mercury Accelsior PCIe 480GB (two no-brand M.2 SSDs in RAID0, what could possible go wrong?) has cost me a lot of data.

Now I'm starting to read posts about Apple having updated the 5,1 UEFI with NVMe booting, and I do recall an update being installed when updating to Mojave.

Does this mean that my upgraded Mac Pro 4,1 now supports NVMe booting too? Or do I need to re-update my UEFI for that?

So, in fact they have the drivers, but won't release them.
Interesting findings

if you have obstructive sleep apnea this best alternative cpap mask

Hi I have attempted to use the 2206-2207 firmware update tool, but i just get an error when it attempts to download the files to make the RAM disk.  Is this now an outdated tool? Is there any other way i can do it.
MacPro1,1 with 2.66 quad Xeons 16gb Ram, 

Guys, if we look at the release of the latest cuda_10.2.89_mac.dmg, we see the following:

Code:

<key>NVDAResmanVersions</key>
<dict>
<key>378.10.10.10.15</key>
<string>378.10.10.10.15</string>
<key>378.10.10.10.20</key>
<string>378.10.10.10.20</string>
<key>378.10.10.10.25</key>
<string>378.10.10.10.25</string>
<key>387.10.10.10</key>
<string>387.10.10.10</string>
<key>387.10.10.15</key>
<string>387.10.10.15</string>
<key>418.15.10</key>
<string>418.15.10</string>
<key>418.20.10</key>
<string>418.20.10</string>
</dict>

And also these files:

Code:

libcuda_418.15.10_mercury.dylib
libcuda_418.20.10_mercury.dylib

So not only there is that 418.15.10 we never figured out where to get, now there is also a 418.20.10...

Edit: Looking further into the binaries I see references that these belong to a r440:

Code:

/dvs/p4/build/sw/rel/gpu_drv/r440/r440_00/drivers/gpgpu/_out/macosx_amd64_release/418.20.10_mercury/cudbgprocess.o

So where do we get these?

Hi I just tried it and it worked like magic!
Many thanks for your help!

I'm more than happy to have helped you! In fact I did this tutorial because I know how it feels
when after spending a couple of hours updating the CPU of the iMac you face that the easiest step
of the process (the EFI update) doesn't work. That's why I wanted to share this tutorial with all you guys.

    Excellent! All hail Master Yoda.

Now there is a date. I got a mail that sais:

«Available to order December 10»

On apple.com it still says "Coming This Fall".

https://www.apple.com/mac-pro/